Run Saber

Run Saber is a 1993 side-scrolling action game developed by Horisoft and published by Atlus for the Super Nintendo Entertainment System. The game was released in North America on June 8, 1993 and in Europe in 1993. In Run Saber, the two main heroes Allen and Sheena, the Run Sabers, fight to save the planet in side-scrolling battles. The gameplay is very similar to Strider.
Story
Years in the future, after Earth has become overly polluted and resources are running low, a scientist quickly finds a solution: a new chemical that can reverse the effects of pollution. As the colonists settle in space to escape the pollution, the newly discovered chemical is launched into the atmosphere in a rocket, where it explodes and is released. However, the chemical begins to horribly mutate all humans infected with it. The scientist knows the effects of his chemical and uses the mutated humans as his soldiers to dominate the Earth. Humanity's only hope is a new weapon known as Project Saber: three human cyborgs genetically engineered to a super-natural level. Kurtz, the first Saber, malfunctions and escapes to Earth before the project is completed. The remaining Sabers, Allen and Sheena, are dispatched to take out the scientist and his militant mutant threat and neutralize Kurtz if possible.